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Genomic analysis of Ugandan and Rwandan chicken ecotypes using a 600 k genotyping array.

D S Fleming1, J E Koltes1,2, A D Markey1

  • 1Iowa State University, Ames, IA, USA.

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|May 28, 2016
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Summary

Indigenous African chickens show genomic adaptations for survival in harsh environments. Selection signatures reveal genes linked to immune function and oxidative stress, aiding adaptation to local conditions.

Keywords:
HomozygositySelection signaturesStress response

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Area of Science:

  • Genomics
  • Animal Genetics
  • Evolutionary Biology

Background:

  • Indigenous animal populations develop unique adaptations to local environmental stressors like heat, drought, and disease.
  • Natural and artificial selection drive the acquisition of favorable traits, leaving genomic signatures in populations.
  • Understanding these adaptations is crucial for livestock resilience and evolution.

Purpose of the Study:

  • To characterize genomic diversity in indigenous chickens from equatorial Africa.
  • To identify genomic regions under selection that may confer adaptive advantages.
  • To understand the genetic basis of adaptation in African chicken ecotypes.

Main Methods:

  • Genotyping of indigenous chickens from Uganda and Rwanda, and Kuroiler chickens using a 600k Chicken Genotyping Array.
  • Analysis of genomic diversity and identification of selection signatures.
  • Gene ontology enrichment analysis of identified genomic regions.

Main Results:

  • Admixture was detected among Ugandan, Rwandan, and Kuroiler chicken populations.
  • Genes in regions of homozygosity are associated with lipid metabolism, immune function, and stress responses.
  • Signatures of selection are enriched for genes involved in health and oxidative stress processes, including antioxidant, apoptosis, and inflammation functions.

Conclusions:

  • Indigenous African chickens possess alleles under environmental selective pressure, facilitating adaptation to harsh conditions.
  • Enriched gene ontology terms related to stress responses suggest common adaptive mechanisms or admixture effects.
  • Genomic insights can inform strategies for improving chicken resilience in challenging environments.