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Updated: Mar 20, 2026
09:51
Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
Published on: May 25, 2018
36.2K
The Smart Programmable CRISPR Technology: A Next Generation Genome Editing Tool for Investigators
Chiranjib Chakraborty1, Seong Lin Teoh2, Srijit Das2
1Department of Bioinformatics, School of Computer and Information Sciences, Galgotias University, Uttar Pradesh, India.
Current Drug Targets
|May 28, 2016
Summary
CRISPR-Cas9 is a revolutionary genome editing tool that offers a simple, cost-effective, and scalable method for targeted genetic manipulation. This technology holds immense promise for advancing drug development and treating diseases.
Area of Science:
- Genomics
- Molecular Biology
- Biotechnology
Background:
- Rapid advancements in genome-editing technology are transforming scientific research.
- CRISPR-Cas9 offers an accessible, cost-effective, and scalable approach to targeted genetic manipulation.
- Its applications span a wide range of genome engineering tasks.
Purpose of the Study:
- To review the structural characteristics, classification, and mechanism of CRISPR-Cas9.
- To highlight its diverse applications in basic science and medicine.
- To discuss future challenges and opportunities for this genome editing toolkit.
Main Methods:
- Review of recent developments in CRISPR-Cas9 technology.
- Discussion of its structural significance and classification.
- Exploration of its mechanism and applications.
Main Results:
- CRISPR-Cas9 represents a paradigm shift in genome editing.
- Its structural features, classification, and applications are detailed.
- The review addresses future challenges for in vivo genome editing.
- The role of CRISPR in disease treatment is emphasized.
Conclusions:
- CRISPR-Cas9 is a highly competent, simple, and low-cost nuclease system.
- It enables precise targeting without off-target mutations.
- This technology is poised to drive next-generation drug development.
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