Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

204
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
204
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

76
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
76
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

73
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
73
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

167
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
167
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

141
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
141
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

179
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
179

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cadaveric investigation of an ultrasound-guided obturator canal approach for obturator nerve block.

Korean journal of anesthesiology·2026
Same author

Successful use of transesophageal echocardiography for minimally invasive cardiac surgery after esophagectomy with gastric tube reconstruction via the retrosternal route: a case report.

JA clinical reports·2026
Same author

Food Packaging Materials for One-Dose Packaging for Enhanced Stability of Hygroscopic Medications.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Linalool inhalation in mice leads to brain accumulation and metabolite-driven neuronal activation.

Biochemical and biophysical research communications·2025
Same author

On the nomenclature of obturator nerve block approach.

Regional anesthesia and pain medicine·2025
Same author

Peptides as functional excipients for drug delivery.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2025

Related Experiment Video

Updated: Mar 20, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.4K

Ion-Responsive Drug Delivery Systems.

Takayuki Yoshida1, Kohsuke Shakushiro1, Kazuhiro Sako2

  • 1Evolving Medical Solutions, Astellas Pharma Inc., Tsukuba, Japan.

Current Drug Targets
|May 28, 2016
PubMed
Summary

Ion-responsive drug delivery systems utilize ions in body fluids to control drug release. These advanced formulations offer improved drug therapy and convenient administration routes for enhanced patient outcomes.

Keywords:
Ion-responsive drug delivery systemcontrolled drug releasein situ gelationion-exchange complexlower critical solution temperatureophthalmic prolonged retentionsalting-out effecttaste-masking

More Related Videos

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

2.0K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.1K

Related Experiment Videos

Last Updated: Mar 20, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.4K
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

2.0K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.1K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmaceutics

Background:

  • Body fluids contain various cations and anions at high concentrations.
  • Ion-responsive drug delivery systems offer unique dosage formulations for optimized drug therapy.
  • These systems aim for effective, safe, and convenient drug administration.

Purpose of the Study:

  • To review and categorize recent research on ion-responsive drug delivery systems.
  • To summarize the mechanisms and applications of ion-responsive formulations.
  • To highlight the advantages of different administration routes.

Main Methods:

  • Literature review of recent research findings on ion-responsive drug delivery.
  • Categorization of polymers and molecules that respond to ions.
  • Analysis of the functions and administration routes of these systems.

Main Results:

  • Ions induce structural changes in formulation polymers/molecules, enabling specific functions.
  • Responsive materials include ion-exchange resins, charged polymers, and metal-organic frameworks.
  • Functions include controlled/site-specific release, in situ gelation, prolonged retention, and enhanced permeation.
  • Successful administration via oral, ophthalmic, transdermal, and nasal routes was demonstrated.

Conclusions:

  • Numerous ion-responsive drug delivery systems have been reported for various administration routes.
  • Advancements in these systems can significantly enhance drug potential.
  • These innovations hold promise for improving patient treatment worldwide.