Association between previous history of gout attack and risk of deep vein thrombosis - a nationwide population-based

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Chun-Chih Chiu1,2, Yung-Tai Chen3,4,5, Chien-Yi Hsu1,5,6

  • 1Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital,Taipei, Taiwan.

Scientific Reports
|May 28, 2016
PubMed

Insights

Gout patients have a significantly higher risk of developing deep vein thrombosis (DVT). This nationwide study found gout increases DVT risk by 1.38-fold, highlighting a crucial link for further research.

Area of Science:

  • Rheumatology
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • The link between hyperuricemia and cardiovascular diseases is known.
  • The association between gout and deep vein thrombosis (DVT) requires further investigation.

Purpose of the Study:

  • To investigate the relationship between gout and the incidence of deep vein thrombosis (DVT).

Main Methods:

  • A nationwide longitudinal cohort study using Taiwan's National Health Insurance Research Database.
  • Identified 35,959 patients with gout and 35,959 matched controls from 2000-2011.
  • Analyzed DVT incidence and risk using Cox proportional hazard models.

Main Results:

  • The incidence rate of DVT was significantly higher in gout patients (13.48 per 10^4 person-years) compared to controls (9.77 per 10^4 person-years).
  • Kaplan-Meier analysis showed a higher tendency for DVT development in gout patients (log rank test, p < 0.001).
  • Patients with gout had a 1.38-fold increased risk of developing DVT (95% CI, 1.18 to 1.62, p < 0.001).

Conclusions:

  • Gout is associated with a significantly increased risk of deep vein thrombosis (DVT).
  • Hyperuricemia associated with gout attacks may be a potential risk predictor for DVT.
  • Further clinical and experimental studies are needed to confirm these findings.

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