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Related Experiment Videos

Pemoline-induced abnormal involuntary movements.

F R Sallee1, R L Stiller, J M Perel

  • 1Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213.

Journal of Clinical Psychopharmacology
|April 1, 1989
PubMed
Summary
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Pemoline medication can cause abnormal involuntary movements, such as choreoathetoid movements, in hyperactive children. These movements resolved after discontinuing pemoline, suggesting a link between the drug and movement disorders.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pediatrics

Background:

  • Hyperactivity is a common concern in pediatric patients.
  • Pemoline has been used to manage symptoms of hyperactivity.
  • Abnormal involuntary movements are a potential adverse effect of certain medications.

Purpose of the Study:

  • To investigate the relationship between pemoline levels and abnormal involuntary movements in hyperactive children.
  • To assess the occurrence of choreoathetoid movements following acute and chronic pemoline exposure.
  • To explore the role of pemoline pharmacokinetics in the development of these movement disorders.

Main Methods:

  • Measured plasma pemoline levels in severely hyperactive males aged 6-12 years.
  • Observed subjects during acute pemoline administration (2 mg/kg orally).

Related Experiment Videos

  • Monitored four chronically treated patients (1.5-2.0 mg/kg/day) for movement abnormalities.

    • Main Results:

    • Five of 20 subjects experienced choreoathetoid movements after acute pemoline exposure.
    • Four chronically treated patients developed choreiform movements and dyskinesias after 3 weeks to 3 months of pemoline use.
    • Abnormal movements ceased after pemoline discontinuation in all affected individuals.
    • Pemoline pharmacokinetics did not appear to be a primary factor in chronic exposure-related movements.

    Conclusions:

    • Pemoline exposure, both acute and chronic, is associated with the development of abnormal involuntary movements in hyperactive children.
    • The total absorbed dose of pemoline may influence the onset of movements after acute exposure.
    • Discontinuation of pemoline leads to the resolution of these movement disorders.