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Mitochondrial vasculopathy.

Josef Finsterer¹, Sinda Zarrouk-Mahjoub¹

¹Josef Finsterer, Krankenanstalt Rudolfstiftung, 1030 Vienna, Austria.

World Journal of Cardiology

|May 28, 2016

Summary

Mitochondrial disorders can affect arteries, causing microvascular or macrovascular issues. Early diagnosis of this mitochondrial vasculopathy is key to preventing severe complications.

Area of Science:

Vascular Biology
Mitochondrial Medicine
Genetics

Background:

Mitochondrial disorders (MIDs) often present as multisystem conditions affecting high-oxygen-demand tissues.
Recently, arterial involvement, termed mitochondrial arteriopathy, has been identified in MID patients.

Purpose of the Study:

To review the types, diagnosis, and treatment of mitochondrial vasculopathy in patients with mitochondrial disorders.
To highlight the clinical manifestations and diagnostic approaches for this rare complication.

Main Methods:

Literature search using relevant keywords to identify studies on mitochondrial vasculopathy.
Analysis of clinical manifestations and diagnostic criteria for mitochondrial arteriopathy.

Main Results:

Keywords:

Angiopathy Arteriopathy Genotype Mitochondrial disorder MtDNA Multisystem Phenotype Vasculopathy

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Mitochondrial vasculopathy presents as either microangiopathy (e.g., leukoencephalopathy, retinopathy) or macroangiopathy (e.g., atherosclerosis, aneurysms).
Diagnosis requires confirming the mitochondrial defect after excluding other causes.

Conclusions:

Mitochondrial vasculopathy is a recognized complication of MIDs, manifesting in small or large arteries.
Accurate diagnosis and timely treatment are essential to mitigate severe vascular complications in MID patients.