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In vivo Raman measurement of levofloxacin lactate in blood using a nanoparticle-coated optical fiber probe
Shupeng Liu1, Ming Rong2, Heng Zhang2
1Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China; liusp@shu.edu.cn.
Abstract:
Monitoring drug concentrations in vivo is very useful for adjusting a drug dosage during treatment and for drug research. Specifically, cutting-edge "on-line" drug research relies on knowing how drugs are metabolized or how they interact with the blood in real-time. Thus, this study explored performing in vivo Raman measurements of the model drug levofloxacin lactate in the blood using a nanoparticle-coated optical fiber probe (optical fiber nano-probe). The results show that we were able to measure real-time changes in the blood concentration of levofloxacin lactate, suggesting that this technique could be helpful for performing drug analyses and drug monitoring in a clinical setting without repeatedly withdrawing blood from patients.
