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Bilateral colobomas in a horse.

¹Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.

Journal of Comparative Pathology

|April 1, 1989

Summary

This study describes bilateral true colobomas and retrobulbar cysts in a horse, leading to progressive blindness. These conditions stem from embryonic fissure closure failure and neuroectoderm eversion, impacting optic nerves and retinal structure.

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Area of Science:

Veterinary Ophthalmology
Equine Pathology
Developmental Biology

Background:

Colobomas are congenital defects resulting from incomplete closure of embryonic fissures.
Retrobulbar cysts can arise secondary to colobomas due to neuroectodermal eversion.
Progressive blindness in horses can have various underlying causes, including congenital abnormalities.

Observation:

An 8-year-old Quarterhorse mare presented with bilateral true colobomas.
Retrobulbar cysts were identified overlying the optic nerves in both eyes.
The mare exhibited a history of progressive vision loss.

Findings:

The colobomas were associated with retrobulbar cysts, suggesting a developmental origin.
Optic nerve size, retinal scarring, rosettes, and disorganization were noted.
The exact etiology of retinal changes (dysplasia vs. secondary degeneration) could not be definitively determined.

Implications:

This case highlights a specific presentation of congenital ocular defects in horses.
Understanding the pathogenesis of colobomas and associated cysts is crucial for equine ophthalmology.
Further research may elucidate the precise mechanisms leading to vision impairment in such cases.

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