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Conjunctival Angioimmunoblastic T-Cell Lymphoma.

Darshak S Patel1, Paul Rundle1, Sachin M Salvi1

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Ocular Oncology and Pathology
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Summary

This report details the first documented case of conjunctival Angioimmunoblastic T-cell lymphoma (AITL), a rare T-cell lymphoma. Early diagnosis requires a high index of suspicion and conjunctival biopsy due to varied presentations.

Keywords:
Angioimmunoblastic T-cell lymphomaConjunctivaDifferential diagnosisEpstein-Barr virusNodular episcleritis

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Area of Science:

  • Oncology
  • Ophthalmology
  • Hematology

Background:

  • Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon T-cell lymphoma typically presenting with systemic symptoms.
  • Conjunctival lymphomas are rare, with diverse clinical presentations.
  • Nodular episcleritis can mimic other ocular conditions.

Observation:

  • This case report describes the first instance of conjunctival AITL.
  • The AITL presented insidiously, mimicking nodular episcleritis.
  • Clinical and pathological findings of this rare presentation are detailed.

Findings:

  • Conjunctival AITL can present atypically, resembling benign ocular inflammation.
  • A thorough ocular examination is crucial for identifying subtle signs of lymphoma.
  • Histopathological analysis of conjunctival biopsy confirmed the AITL diagnosis.

Implications:

  • Highlights the importance of considering rare diagnoses in ophthalmology.
  • Emphasizes the need for a high index of suspicion for conjunctival lymphoma.
  • Underscores the diagnostic value of conjunctival biopsy in suspected cases.