Related Experiment Video
Updated: Mar 20, 2026
08:55
High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
Published on: October 9, 2020
6.2K
One- and Two-Dimensional Nuclear Magnetic Resonance Spectroscopy with a Diamond Quantum Sensor
J M Boss1, K Chang1, J Armijo2
1Department of Physics, ETH Zurich, Otto Stern Weg 1, 8093 Zurich, Switzerland.
Physical Review Letters
|May 28, 2016
Summary
Researchers used Fourier spectroscopy with nitrogen-vacancy centers in diamond to identify nuclear magnetic resonance (NMR) species. This method precisely measures hyperfine coupling and Larmor frequency, enabling potential atomic-level imaging of molecules.
Area of Science:
- Quantum sensing
- Spectroscopy
- Materials science
Background:
- Nitrogen-vacancy (NV) centers in diamond are promising quantum sensors.
- Traditional quantum sensing protocols can be complex and prone to artifacts like harmonics.
- Precise characterization of nuclear spins is crucial for nanoscale applications.
Purpose of the Study:
- To develop a novel Fourier spectroscopy technique for nuclear spin analysis.
- To demonstrate unambiguous identification of NMR species.
- To achieve high-precision measurement of hyperfine coupling and nuclear Larmor frequency.
Main Methods:
- Utilizing near-surface nitrogen-vacancy centers in a diamond chip.
- Employing free nuclear spin precession detection instead of multipulse protocols.
- Engineering Hamiltonians to control and measure spin dynamics.
- Combining protocols for two-dimensional Fourier spectroscopy.
Main Results:
- Unambiguous identification of NMR species without harmonic contamination.
- Selective measurement of hyperfine coupling parameters with high precision (up to five digits).
- Selective measurement of nuclear Larmor frequency with high precision (up to five digits).
- Demonstration of combined protocols for 2D Fourier spectroscopy.
Conclusions:
- The developed Fourier spectroscopy technique offers a precise and robust method for nuclear spin analysis.
- This technique overcomes limitations of traditional quantum sensing protocols.
- The presented methods pave the way for mapping nuclear coordinates and atomic-level imaging of molecules on diamond sensor chips.
Related Concept Videos
01:12Two-Dimensional (2D) NMR: Overview
1.7K
The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
1.7K
01:162D NMR: Overview of Homonuclear Correlation Techniques
770
Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
COSY90 is the standard two-dimensional (2D) COSY experiment that...
770
01:192D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)
1.6K
Heteronuclear single-quantum correlation spectroscopy (HSQC) is a 2D NMR technique that reveals one-bond correlations between hydrogen and a heteronucleus. The HSQC experiment is similar to the heteronuclear correlation experiment (HETCOR) but is more sensitive. In the HSQC spectrum, the proton chemical shift is plotted on the horizontal F2 axis, while the 13C chemical shift is plotted on the vertical F1 axis. The corresponding proton and 13C spectra are also shown. The HSQC contour plot does...
1.6K
01:182D NMR: Overview of Heteronuclear Correlation Techniques
877
Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other...
877
01:02¹H NMR: Interpreting Distorted and Overlapping Signals
1.7K
Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
1.7K
01:12Double Resonance Techniques: Overview
835
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
Spin decoupling is usually achieved by...
835