Related Experiment Video
Updated: Mar 20, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
Angiotensin-converting enzyme (ACE-I/D) polymorphism frequency in Brazilian soccer players
Daniel Barbosa Coelho1, Eduardo Pimenta2, Izinara Cruz Rosse3
1a Sports Center, Federal University of Ouro Preto, CEP-35400-000 Minas Gerais, Brazil.
This study examined angiotensin-converting enzyme (ACE-I/D) gene variations in Brazilian soccer players across various age groups. No significant differences in ACE-I/D allele or genotype frequencies were found compared to a control group.
Area of Science:
- Sports Science
- Genetics
- Human Physiology
Background:
- The angiotensin-converting enzyme (ACE) gene, specifically the I/D polymorphism, is investigated for its potential role in athletic performance.
- Understanding the genetic makeup of elite athletes can provide insights into performance-related traits.
Purpose of the Study:
- To determine the allelic and genotypic frequencies of the ACE gene (I/D polymorphism) in Brazilian soccer players of different age categories.
- To compare these frequencies with a control group to identify any potential genetic associations with soccer participation in Brazil.
Main Methods:
- Genotyping of the ACE I/D polymorphism was performed on 353 Brazilian soccer players.
- Players were categorized into Under-14, Under-15, Under-17, Under-20, and professional levels.
- Allelic and genotypic frequencies were statistically compared between player categories and a control group.
Main Results:
- No statistically significant differences were observed in ACE-I/D allelic frequencies across any of the player age categories when compared to the control group.
- Similarly, no significant differences in ACE-I/D genotypic frequencies were found between the soccer players and the control group.
- This marks the first investigation into ACE-I/D polymorphism specifically within Brazilian soccer players.
Conclusions:
- The ACE-I/D polymorphism does not appear to be a significant factor differentiating Brazilian soccer players from the general population across various age groups.
- Further research may be warranted to explore other genetic markers or environmental factors influencing soccer talent in Brazil.
Related Concept Videos
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Antihypertensive Drugs: Direct Renin Inhibitors
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

