Related Experiment Video

Updated: Sep 3, 2026

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography
06:44

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Published on: April 13, 2018

10.6K

A review of the venous thrombotic issues associated with multiple myeloma

Despina Fotiou1, Grigoris Gerotziafas2,3, Efstathios Kastritis1

  • 1a Department of Clinical Therapeutics , National and Kapodistrian University of Athens, School of Medicine , Athens , Greece.

Expert Review of Hematology
|May 28, 2016
PubMed
Abstract

Insights

Patients with multiple myeloma face a high risk of venous thromboembolism (VTE), especially when treated with immunomodulatory drugs. Current prophylaxis methods are insufficient, highlighting the need for better risk assessment and biomarker research.

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Multiple myeloma (MM) patients have a significantly increased risk of venous thromboembolic (VTE) complications.
  • VTE rates have risen with the use of novel agents, particularly immunomodulatory drugs (IMiDs) like thalidomide, lenalidomide, and pomalidomide.

Purpose of the Study:

  • To highlight the persistent challenge of VTE in multiple myeloma despite current prophylaxis strategies.
  • To emphasize the critical need to differentiate between intrinsic VTE risk in MM and therapy-induced risk.

Main Methods:

  • Review of current thromboprophylaxis recommendations for IMiD-based regimens in MM.
  • Analysis of risk factors influencing VTE in MM patients.
  • Discussion of the limitations of existing prophylaxis drugs (aspirin, LMWH, warfarin).

Main Results:

  • Standard thromboprophylaxis, while recommended, does not completely eliminate VTE events in MM patients.
  • Distinguishing intrinsic MM thrombosis risk from treatment effects is crucial for effective prevention.

Conclusions:

  • Current thromboprophylaxis strategies for MM are not fully effective in preventing VTE.
  • Further research into biomarkers and integrated risk assessment models is essential to identify high-risk patients who would benefit most from intensified prophylaxis.
Keywords:
MicroparticlesMultiple myelomaimmunomodulatory drugsrisk assessment modelsthromboprophylaxisvenous thromboembolism

More Related Videos

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

7.3K
Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

3.4K

Related Concept Videos

Overview of Systemic Veins01:11

Overview of Systemic Veins

Systemic veins are crucial blood vessels that return deoxygenated blood from various body tissues back to the heart. There are three systemic veins that return deoxygenated blood to the heart, they are as follows.
The coronary sinus, the heart's principal vein, resides in the coronary sulcus on the heart's posterior aspect. This broad venous channel receives nearly all venous blood from the myocardium, the heart muscle. It is fed by three primary veins: the great cardiac vein, the middle...
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...