Related Experiment Video

Updated: Mar 20, 2026

Fluorescent Visualization of Mango-tagged RNA in Polyacrylamide Gels via a Poststaining Method
06:06

Fluorescent Visualization of Mango-tagged RNA in Polyacrylamide Gels via a Poststaining Method

Published on: June 21, 2019

9.1K

Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas

Hesham Saleh1, Daniel Petras1, Andi Mainz1

  • 1Institut für Chemie, Technische Universität Berlin , Strasse des 17. Juni 124, 10623 Berlin, Germany.

Journal of Natural Products
|May 28, 2016
PubMed

Insights

Researchers discovered xanthomonic acid, a novel natural product from the mango pathogen Xanthomonas citri pv. mangiferaeindicae. This compound, an isoprenylated para-aminobenzoic acid derivative, shows in vitro anticancer activity by inducing autophagy in human cancer cells.

Area of Science:

  • Natural Product Chemistry
  • Microbiology
  • Cancer Biology

Background:

  • Xanthomonas citri pv. mangiferaeindicae is a significant mango pathogen.
  • Natural products often possess unique chemical structures and biological activities.

Purpose of the Study:

  • To identify and characterize novel natural products from Xanthomonas citri pv. mangiferaeindicae.
  • To investigate the biological activity of the isolated compounds.

Main Methods:

  • Stable isotope precursor feeding.
  • Nontargeted Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS).
  • Molecular networking for spectral data visualization.
  • In vitro cytotoxicity assays.

Main Results:

  • Identification of a new meroterpenoid, xanthomonic acid.
  • Xanthomonic acid is an isoprenylated para-aminobenzoic acid derivative.
  • Xanthomonic acid exhibited in vitro cytotoxicity against human cancer cell lines.

Conclusions:

  • Xanthomonic acid is a novel natural product with potential anticancer properties.
  • The compound exerts its cytotoxic effect through the induction of autophagy.
  • This discovery opens avenues for further research into natural product-based cancer therapeutics.

More Related Videos

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

10.5K
MALDI-Mass Spectrometric Imaging for the Investigation of Metabolites in Medicago truncatula Root Nodules09:59

MALDI-Mass Spectrometric Imaging for the Investigation of Metabolites in Medicago truncatula Root Nodules

Published on: March 5, 2014

19.6K

Related Concept Videos

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.8K