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Malignant pleural mesothelioma: initial experience in integrated (18)F-FDG PET/MR imaging

Benedikt M Schaarschmidt1, Lino M Sawicki2, Benedikt Gomez3

  • 1University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225 Dusseldorf, Germany; University Duisburg-Essen, Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, D-45147 Essen, Germany.

Clinical Imaging
|May 28, 2016
PubMed
Abstract

Insights

Integrated PET/MR staging for malignant pleural mesothelioma (MPM) is comparable to PET/CT. A significant inverse correlation between apparent diffusion coefficient (ADC) and standardized uptake value (SUV) suggests potential for multiparametric response assessment.

Area of Science:

  • Oncology
  • Radiology
  • Medical Imaging

Background:

  • Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer.
  • Accurate staging is crucial for treatment planning and prognosis in MPM.
  • Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) is a standard imaging modality for MPM staging.

Purpose of the Study:

  • To compare the staging accuracy of integrated (18)F-FDG PET/CT and PET/Magnetic Resonance (MR) imaging in patients with MPM.
  • To investigate the correlation between apparent diffusion coefficient (ADC) and standardized uptake value (SUV) in MPM lesions.

Main Methods:

  • Six patients diagnosed with MPM underwent both (18)F-FDG PET/CT and integrated PET/MR imaging, including diffusion-weighted imaging (DWI).
  • Thoracic TNM staging was performed independently for both imaging modalities.
  • SUVmax and ADCmin values were quantified in therapy-naive pleural lesions.

Main Results:

  • No significant differences were observed in thoracic TNM staging between PET/CT and PET/MR.
  • A statistically significant inverse correlation was found between mean SUV (SUVmean) and minimum ADC (ADCmin) (r=-0.63, P=.002).

Conclusions:

  • Integrated PET/MR imaging is a feasible and effective tool for staging malignant pleural mesothelioma.
  • The observed inverse correlation between ADC and SUV suggests that multiparametric imaging may offer new insights into therapy response evaluation in MPM.
Keywords:
DWIMPMMesotheliomaPET/CTPET/MRPET/MRI

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