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Where does current and future pediatric asthma treatment stand? Remodeling and inflammation: Bird's eye view

Ozge Yilmaz1, Hasan Yuksel1

  • 1Department of Pediatric Allergy and Pulmonology, Celal Bayar University Medical Faculty, Manisa, Turkey.

Pediatric Pulmonology
|May 28, 2016
PubMed

Insights

Pediatric asthma involves airway remodeling due to inflammation. This review examines current and future therapies to interrupt this process in children, highlighting the need for personalized treatment approaches.

Area of Science:

  • Pediatric Pulmonology
  • Asthma Research
  • Inflammation and Remodeling

Background:

  • Airway remodeling is a chronic consequence of asthma-related inflammation.
  • The transition from pediatric to adult age presents a critical window for intervention.
  • Understanding pediatric asthma is key to interrupting airway remodeling.

Purpose of the Study:

  • To review the impact of current and emerging therapies on airway inflammation and remodeling in pediatric asthma.
  • To address the heterogeneity in research findings by considering individual pathogenetic characteristics.
  • To emphasize the need for individualized treatment strategies in pediatric asthma management.

Main Methods:

  • Systematic review of experimental and clinical research.
  • Assessment of current therapeutic modalities for asthma.
  • Evaluation of newly developed therapeutic agents.

Main Results:

  • Varied results in studies suggest heterogeneous pathogenesis of asthma and remodeling.
  • Current therapies show potential but require tailored application.
  • New agents demonstrate promising outcomes for managing pediatric asthma.

Conclusions:

  • Individualized treatment is crucial due to the diverse nature of pediatric asthma.
  • Therapeutic strategies must target both inflammation and airway remodeling.
  • Further research into novel agents and personalized approaches is warranted.

Keywords:
Pediatric asthmacurrentfutureinflammationremodelingtreatment

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