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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Vaccinations01:51

Vaccinations

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Overview
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Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

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Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
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Humoral Immune Responses01:36

Humoral Immune Responses

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Overview
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Mar 20, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

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Immunisation of the immunocompromised child.

Marta Valente Pinto1, Smiti Bihari1, Matthew D Snape1

  • 1Oxford Vaccine Group, Department of Paediatrics, University of Oxford, OX3 7LE, United Kingdom.

The Journal of Infection
|May 29, 2016
PubMed
Summary

Vaccines are crucial for immunocompromised children, who face higher infection risks. This review details live and non-live vaccine considerations, safety, and effectiveness for this vulnerable population.

Keywords:
ChildrenImmunocompromisedImmunogenicityRecommendationsSafetyVaccines

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Area of Science:

  • Pediatrics
  • Immunology
  • Infectious Diseases

Background:

  • Immunocompromised children are at increased risk of severe infections, mortality, and morbidity.
  • Vaccine administration is critical for preventing infections in this population.
  • Specialized considerations for immunizations are necessary for immunocompromised children.

Purpose of the Study:

  • To review vaccines relevant to immunocompromised hosts.
  • To cover both live and non-live vaccines.
  • To provide comprehensive information on vaccine use in immunocompromised children.

Main Methods:

  • Literature review summarizing vaccines for immunocompromised hosts.
  • Inclusion of live and non-live vaccine types.
  • Description of disease burden, safety, and immunogenicity/effectiveness.

Main Results:

  • Detailed information on relevant vaccines for immunocompromised children.
  • Assessment of vaccine safety and immunogenicity/effectiveness.
  • Summary of specific recommendations and guidelines from various organizations.

Conclusions:

  • Immunocompromised children require careful vaccine selection and administration.
  • Understanding vaccine benefits, risks, and efficacy is crucial.
  • Adherence to updated guidelines ensures optimal protection against infections.