Immunisation of the immunocompromised child
Marta Valente Pinto1, Smiti Bihari1, Matthew D Snape1
1Oxford Vaccine Group, Department of Paediatrics, University of Oxford, OX3 7LE, United Kingdom.
Insights
Vaccines are crucial for immunocompromised children, who face higher infection risks. This review details live and non-live vaccine considerations, safety, and effectiveness for this vulnerable population.
Area of Science:
- Pediatrics
- Immunology
- Infectious Diseases
Background:
- Immunocompromised children are at increased risk of severe infections, mortality, and morbidity.
- Vaccine administration is critical for preventing infections in this population.
- Specialized considerations for immunizations are necessary for immunocompromised children.
Purpose of the Study:
- To review vaccines relevant to immunocompromised hosts.
- To cover both live and non-live vaccines.
- To provide comprehensive information on vaccine use in immunocompromised children.
Main Methods:
- Literature review summarizing vaccines for immunocompromised hosts.
- Inclusion of live and non-live vaccine types.
- Description of disease burden, safety, and immunogenicity/effectiveness.
Main Results:
- Detailed information on relevant vaccines for immunocompromised children.
- Assessment of vaccine safety and immunogenicity/effectiveness.
- Summary of specific recommendations and guidelines from various organizations.
Conclusions:
- Immunocompromised children require careful vaccine selection and administration.
- Understanding vaccine benefits, risks, and efficacy is crucial.
- Adherence to updated guidelines ensures optimal protection against infections.
Abstract:
Immunocompromised children have a higher risk of developing infections and associated higher rates of mortality and morbidity. Although this group could benefit the most from vaccine administration, specific considerations regarding immunisations are required. This review is a summary of the vaccines that are relevant to the immunocompromised host, covering both live and non-live vaccines. The burden of disease, safety, immunogenicity/effectiveness and specific recommendations for each vaccine are described as well as specific guidelines from different organisations.
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