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[Angiosarcoma of the breast].

B Malavaud1, A Pessonnier, P Martel

  • 1Centre Claudius Regaud, Toulouse.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|January 1, 1989
PubMed
Summary
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Angiosarcoma of the breast is a rare, fast-growing tumor primarily affecting young women. Early diagnosis via histology is crucial for managing this aggressive cancer with a poor prognosis.

Area of Science:

  • Oncology
  • Pathology

Background:

  • Angiosarcoma of the breast is an exceptionally rare connective tissue tumor, with fewer than 100 cases documented.
  • This malignancy predominantly affects women, often presenting as a rapidly growing phylloid tumor in younger individuals.

Observation:

  • Clinical presentation can include inflammatory signs, and local trauma is frequently cited as a potential factor.
  • Diagnosis is challenging, relying heavily on histological examination of biopsy or surgical specimens.
  • Microscopic differentiation from benign hemangioma requires careful evaluation of multiple tissue sections.

Findings:

  • The study highlights a case of breast angiosarcoma in a 37-year-old woman with a rapidly enlarging, poorly defined, multinodular, non-inflammatory mass.
  • Expert histological review facilitated diagnosis within one month of symptom onset.

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  • Standard treatment involves mastectomy, often without axillary lymph node dissection, followed by polychemotherapy.

    • Implications:

    • The prognosis for breast angiosarcoma remains grave, with a median survival of approximately 22 months.
    • While radiotherapy and hormone therapy are debated, chemotherapy is a standard component of treatment.
    • Accurate and timely histological diagnosis is paramount for effective management of this rare breast cancer.