Related Experiment Video
Updated: Jul 27, 2026
Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures
Published on: October 3, 2016
Survey of laboratory-acquired infections around the world in biosafety level 3 and 4 laboratories
1URMITE, CNRS UMR 7278, IRD 198, Inserm 1095, Aix Marseille Université, IHU Méditerranée Infection, 27 bd Jean Moulin, 13005, Marseille, France.
Abstract:
Laboratory-acquired infections due to a variety of bacteria, viruses, parasites, and fungi have been described over the last century, and laboratory workers are at risk of exposure to these infectious agents. However, reporting laboratory-associated infections has been largely voluntary, and there is no way to determine the real number of people involved or to know the precise risks for workers. In this study, an international survey based on volunteering was conducted in biosafety level 3 and 4 laboratories to determine the number of laboratory-acquired infections and the possible underlying causes of these contaminations. The analysis of the survey reveals that laboratory-acquired infections have been infrequent and even rare in recent years, and human errors represent a very high percentage of the cases. Today, most risks from biological hazards can be reduced through the use of appropriate procedures and techniques, containment devices and facilities, and the training of personnel.
Insights
Laboratory-acquired infections are rare, with human error being the primary cause. Implementing proper procedures, containment, and training significantly reduces risks for laboratory workers handling infectious agents.
Area of Science:
- Occupational Health
- Infectious Disease Epidemiology
- Biosafety
Background:
- Laboratory workers face risks from infectious agents like bacteria, viruses, parasites, and fungi.
- Historically, voluntary reporting has limited understanding of laboratory-associated infection prevalence and risks.
Purpose of the Study:
- To quantify laboratory-acquired infections in biosafety level 3 and 4 laboratories.
- To identify underlying causes of contamination in high-containment facilities.
Main Methods:
- An international, voluntary survey was conducted among personnel in biosafety level 3 and 4 laboratories.
- Data collected focused on infection incidence and potential causes of exposure.
Main Results:
- Laboratory-acquired infections are infrequent and rare in recent years.
- Human error accounts for a high percentage of reported laboratory-associated infections.
Conclusions:
- While rare, laboratory-acquired infections remain a concern.
- Effective risk mitigation involves robust procedures, containment, and comprehensive personnel training.
Related Concept Videos
01:25Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
01:26Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
01:23Investigation of Disease Outbreaks