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Related Concept Videos

Viral Meningitis01:18

Viral Meningitis

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Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
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Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

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The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
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Updated: Mar 20, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
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[Multiple meningiomas].

L-M Terrier1, P François1

  • 1Service de neurochirurgie, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours cedex 9, France.

Neuro-Chirurgie
|May 29, 2016
PubMed
Summary
This summary is machine-generated.

Multiple meningiomas (MMs) are rare brain tumors, often benign, with unclear origins. Treatment focuses on individual lesions, not aggressive resection of all, unless specific risk factors are present.

Keywords:
Brain tumorsHistoire naturelleHormonesMeningiomaMultiple meningiomasMéningiomeMéningiomes multiplesNatural historyRadiation-induced tumorTumeur radio-induiteTumeurs cérébrales

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Area of Science:

  • Neurosurgery
  • Oncology
  • Genetics

Background:

  • Multiple meningiomas (MMs), or meningiomatosis, involve at least two intracranial lesions without neurofibromatosis.
  • They account for 1-9% of all meningiomas, with a higher incidence in females.
  • Etiology remains unclear, with hypotheses including independent tumor evolution or cerebrospinal fluid seeding.

Purpose of the Study:

  • To summarize the current understanding of multiple meningiomas, including their etiology, risk factors, clinical presentation, histology, and prognosis.
  • To emphasize individualized treatment approaches for each meningioma lesion.

Main Methods:

  • Literature review and synthesis of existing research on multiple meningiomas.
  • Analysis of etiological hypotheses, risk factors (NF2 gene mutations, ionizing radiation), and prognostic indicators.

Main Results:

  • NF2 gene mutations are an intrinsic risk factor; ionizing radiation is a proven exogenous risk factor.
  • Histologic types are similar to solitary meningiomas; most are benign.
  • Prognosis is generally good, comparable to solitary tumors, except in radiation-induced cases, NF2 contexts, or pediatric diagnoses.

Conclusions:

  • Individual meningioma lesions should be managed independently.
  • The presence of multiple lesions does not automatically warrant aggressive, complete surgical resection.