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[A clinical study evaluating bone mineral mass in the radius during skeletal growth--single photon absorptiometry]
1Department of Orthopedic Surgery, Tottori University School of Medicine, Japan.
Insights
Bone mineral content in Japanese children increases with age, with distinct growth patterns in the radius metaphysis and diaphysis. Certain medical conditions and therapies can negatively impact bone mass development.
Area of Science:
- Pediatric Endocrinology
- Bone Densitometry
- Radiological Imaging
Context:
- Assessing bone mineral content (BMC) is crucial for understanding pediatric skeletal development.
- 125-I single photon absorptiometry is a validated technique for bone densitometry in children.
- Establishing normative data for bone mineral measurements in diverse pediatric populations is essential.
Purpose:
- To measure bone mineral content (BMC), bone width (BW), and BMC/BW ratios in healthy Japanese children aged 2 to 19 years.
- To analyze the relationship between bone mass and anthropometric factors like height and weight.
- To investigate the impact of medical conditions and therapies on pediatric bone mineral accrual.
Summary:
- Bone mineral measurements (BMC, BW, BMC/BW) were conducted on 206 healthy Japanese children using 125-I single photon absorptiometry.
- Diaphyseal bone mass increased linearly, while metaphyseal bone mass showed a steep rise during puberty.
- Reduced bone mass was observed in children on glucocorticoid or anticonvulsant therapy, and in those with endocrine disorders (hypopituitarism, hypothyroidism, hyperthyroidism, Turner's syndrome).
Impact:
- Provides normative bone mineral data for Japanese children, aiding in the diagnosis of skeletal abnormalities.
- Highlights the detrimental effects of certain medications and endocrine disorders on bone development.
- Informs clinical practice regarding monitoring bone health in children undergoing long-term therapies or with specific medical conditions.
Abstract:
Using 125-I single photon absorptiometry, bone mineral measurements were performed on 206 healthy Japanese children (2 to 19 years of age). Bone mineral content (BMC), bone width (BW) and BMC/BW values were determined for the radius at distal 1/6 site (metaphysis) and distal 1/3 site (diaphysis). BMC/BW values at both sites correlated well with body height and weight. Bone mass in the diaphysis (distal 1/3 site) increased linearly during the 2-19 years of skeletal growth, but bone mass in the metaphysis (1/6 site) increased steeply during the pubertal period. In children receiving glucocorticoid therapy, bone mass was reduced in proportion to the duration of drug administration. In children under anticonvulsant therapy, the yearly increase in bone mass was significantly low especially in those patients with poor physical activity levels. Bone mineral decrease in the radius occurred in the children with hypopituitalism, hypothyroidism (cretinism), hyperthyroidism and Turner's syndrome.