Related Experiment Video
Updated: Mar 20, 2026
Use of Bisection to Reduce Mitochondrial DNA in the Bovine Oocyte
Published on: July 6, 2022
Experimental strategies towards increasing intracellular mitochondrial activity in oocytes: A systematic review
Sara Darbandi1, Mahsa Darbandi1, Hamid Reza Khorram Khorshid2
1Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Purpose:
The mitochondrial complement is critical in sustaining the earliest stages of life. To improve the Assisted Reproductive Technology (ART), current methods of interest were evaluated for increasing the activity and copy number of mitochondria in the oocyte cell.
Methods:
This covered the researches from 1966 to September 2015.
Results:
The results provided ten methods that can be studied individually or simultaneously.
Conclusion:
Though the use of these techniques generated great concern about heteroplasmy observation in humans, it seems that with study on these suggested methods there is real hope for effective treatments of old oocyte or oocytes containing mitochondrial problems in the near future.
