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Related Experiment Videos

Development and evaluation of a dual-pump microcomputer-based closed-loop arterial pressure control system.

J R Colvin1, G N Kenny

  • 1University Department of Anaesthesia, Glasgow Royal Infirmary, Scotland, UK.

International Journal of Clinical Monitoring and Computing
|January 1, 1989
PubMed
Summary

A novel computer system effectively controls hypertension post-cardiac surgery using two vasodilators. This automated method offers a safe and efficient alternative for managing blood pressure in patients after cardiopulmonary bypass.

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Area of Science:

  • Cardiovascular Surgery
  • Medical Informatics
  • Pharmacology

Background:

  • Post-cardiac surgery hypertension is common and increases patient morbidity.
  • Short-acting vasodilators are typically used for management.
  • Computer-controlled infusion systems show promise compared to manual control.

Purpose of the Study:

  • To develop and evaluate a closed-loop computer system for controlling arterial pressure.
  • To enable simultaneous infusion of two vasodilators.
  • To assess the safety and efficacy of automated dual-vasodilator administration.

Main Methods:

  • Developed a closed-loop system using an ATARI 1040ST microcomputer and a proportional-integral-derivative algorithm.
  • Controlled two IMED 929 infusion pumps via one RS-232 port.

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  • Collected cardiovascular data online and used a mouse for user interface.

    • Main Results:

    • The system successfully managed hypertension in 24 patients post-cardiopulmonary bypass.
    • Glyceryl trinitrate (GTN) alone controlled hypertension in 14 patients.
    • Sodium nitroprusside (SNP) was required as a supplement in 10 patients.

    Conclusions:

    • The dual-pump automatic arterial pressure control system is a safe and satisfactory method.
    • Simultaneous administration of two vasodilators is feasible with this automated system.
    • The system is suitable for both clinical and research applications in managing post-cardiac surgery hypertension.