Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

10.3K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
10.3K
Glial Cells01:04

Glial Cells

96.3K
Overview
96.3K
T Cell Types and Functions01:24

T Cell Types and Functions

3.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microbiota-Gut-Brain Axis in Neurodegenerative Diseases: The Role of Bacterial Amyloids.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Elevated levels of colonic interleukin-1beta and interleukin-8 in isolated REM sleep behavior disorder without associated changes in permeability.

NPJ Parkinson's disease·2026
Same author

The short-chain fatty acid butyrate prevents gut-brain amyloid-β pathology and neuroinflammation in an Alzheimer mouse model.

Molecular psychiatry·2026
Same author

enGLOW 3D microscopy of the enteric nervous system in cleared human and mouse gut.

Communications biology·2026
Same author

Optimization of α-Synuclein and Tau Detection by Immunoblot in Enteroendocrine Cell Lines.

Neurogastroenterology and motility·2026
Same author

The Microbiota-Derived Metabolite Deoxycholic Acid Regulates Enteric Neuron Activity and Connectivity.

Journal of neurochemistry·2026

Related Experiment Video

Updated: Mar 20, 2026

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse
07:53

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Published on: August 15, 2018

14.7K

Enteric glial cells have specific immunosuppressive properties.

Laetitia Kermarrec1, Tony Durand1, Michel Neunlist1

  • 1INSERM, UMR 913, Nantes F-44035, France; Université de Nantes, Faculté de Médecine, Nantes F-44035, France; CHU de Nantes, Institut des Maladies de l'Appareil Digestif, IMAD, Nantes F-44093, France.

Journal of Neuroimmunology
|May 29, 2016
PubMed
Summary
This summary is machine-generated.

Enteric glial cells (EGC) inhibit T lymphocyte proliferation. EGC from Crohn's patients show enhanced immunosuppressive properties, suggesting a role in inflammatory bowel disease immune homeostasis.

Keywords:
Enteric glial cellsImmunoregulationInflammatory bowel diseasesT cell

More Related Videos

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
08:00

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

Published on: June 4, 2020

4.0K
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

16.7K

Related Experiment Videos

Last Updated: Mar 20, 2026

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse
07:53

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Published on: August 15, 2018

14.7K
Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
08:00

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

Published on: June 4, 2020

4.0K
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

16.7K

Area of Science:

  • Neurogastroenterology
  • Immunology
  • Gastroenterology

Background:

  • Enteric glial cells (EGC) are crucial for the enteric nervous system's function.
  • The direct impact of EGC on immune cell activity remains largely unexplored.

Purpose of the Study:

  • To investigate the direct effect of human EGC on activated T lymphocyte proliferation.
  • To compare the immunomodulatory capacity of EGC from healthy individuals and Crohn's disease patients.

Main Methods:

  • Co-culture systems were employed to assess interactions between human EGC and activated T lymphocytes.
  • The proliferation of T lymphocytes was measured in the presence of varying ratios of EGC.

Main Results:

  • Human EGC demonstrated an inhibitory effect on the proliferation of activated T lymphocytes.
  • EGC derived from Crohn's disease patients exhibited a significantly higher capacity to inhibit T lymphocyte proliferation compared to EGC from control subjects.

Conclusions:

  • Enteric glial cells play a role in maintaining immune homeostasis within the gastrointestinal tract.
  • EGC may possess distinct immunosuppressive properties relevant to the pathogenesis of inflammatory bowel diseases like Crohn's disease.