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Updated: Mar 20, 2026

Ultrasound Assessment of Flow-Mediated Dilation of the Brachial and Superficial Femoral Arteries in Rats
Published on: November 3, 2016
Femoral Artery Ultrasound Examination
Pierleone Lucatelli1, Corrado Fagnani2, Adam Domonkos Tarnoki3
11 Department of Radiology, Oncology and Anatomic Pathology, Vascular and Interventional Radiology Unit, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Insights
In healthy individuals, atherosclerotic plaques are more common in the common femoral artery (CFA) than the common carotid artery (CCA). This suggests CFA ultrasonography may aid cardiovascular risk screening.
Area of Science:
- Vascular Biology and Atherosclerosis
- Cardiovascular Imaging and Diagnostics
Background:
- Intima-media thickness (IMT) and plaque prevalence are key indicators of subclinical atherosclerosis.
- Previous research has primarily focused on carotid arteries, with less attention to femoral arteries in healthy populations.
Purpose of the Study:
- To compare intima-media thickness (IMT) and atherosclerotic plaque prevalence between the common carotid artery (CCA) and common femoral artery (CFA) in apparently healthy adults.
- To evaluate the potential role of CFA ultrasonography in cardiovascular risk assessment.
Main Methods:
- Multicenter study involving 322 healthy participants (mean age 52.1 years).
- Echo-color Doppler examination of bilateral CCA and CFA.
- Assessment of plaque prevalence, composition, and IMT.
Main Results:
- Mean CFA-IMT (0.73 mm) was significantly higher than mean CCA-IMT (0.70 mm) (P < .01).
- Plaque prevalence was significantly higher in the CFA (40.7%) compared to the CCA (30.4%).
- Atherosclerotic plaques were found in CFA only in 38% of cases, and in both arteries in 46%.
Conclusions:
- Atherosclerotic plaques are more prevalent in the CFA than the CCA in a healthy population.
- Over one-third of healthy individuals exhibited plaques in the CFA but not the CCA.
- Further research is warranted to determine if CFA ultrasonography can be integrated into cardiovascular risk screening protocols.
Abstract:
We compared intima-media thickness (IMT) and the prevalence of plaques in the common carotid artery (CCA) and common femoral artery (CFA) in apparently healthy participants. This multicenter study included 322 participants (59.9% female; age 20-78 years, mean 52.1 ± 15.3 years) who underwent Echo-color Doppler examination of the CCA and CFA bilaterally. Prevalence and composition of plaque were recorded. A significant ( P < .01) difference between mean CCA-IMT and mean CFA-IMT was detected (0.70 vs 0.73 mm). Plaque prevalence was significantly higher in the CFA compared to the CCA (40.7% vs 30.4%). Atherosclerotic plaques were found in both CFA and CCA in 46% of the cases, solely in CFA in 38%, and in CCA alone in 17%. The observed difference in plaque prevalence was even greater when only fibrolipid isolated plaques were considered (CFA 39.4% vs CCA 22.1%). In a healthy general population, atherosclerotic plaques were present in the CFA but not in the CCA in over one-third of the cases. Further studies must confirm whether ultrasonography of the CFA might be introduced in the screening protocols for cardiovascular risk assessment.
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