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Updated: Mar 20, 2026

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
Published on: December 29, 2021
[Co-occurrent cannabis and tobacco uses: Clinical knowledge and therapeutic prospects]
Thomas Schwitzer1, Claudine Gillet2, Michaël Bisch2
1EA7298, INGRES, université de Lorraine, 54500 Vandœuvre-lès-Nancy, France; Centre psychothérapique de Nancy, 54521 Laxou, France; Inserm U1114, département de psychiatrie, fédération de médecine translationnelle de Strasbourg, centre hospitalier régional universitaire de Strasbourg, 67000 Strasbourg, France.
Abstract:
Cannabis and tobacco are two of the most prevalent addictive drugs used worldwide. Concurrent use of cannabis and tobacco is common, whether simultaneous in joints or not. In France, cannabis is mainly used in joints also containing tobacco. According to the current literature, combined use of cannabis and tobacco exacerbates on additive or multiplicative mode the somatic, psychological and social consequences of each drug. In addition, concurrent use of cannabis and tobacco potentiates tobacco and cannabis dependence, which maintains the use of both drugs, increases the risk of relapse and reduces motivation to care. Combined use thus leads to a reduced likelihood of therapeutic success. We discuss the usefulness of simultaneous cessation treatment together with the use of currently available pharmacological and psychological help as valuable therapeutic tools.
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