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Fusarium spp infections in a pediatric burn unit: nine years of experience

María Teresa Rosanova1, Martín Brizuela1, Mabel Villasboas2

  • 1Hospital de Pediatría "Prof. Dr. Juan P. Garrahan" , Departamento de Enfermedades Infecciosas, Buenos Aires, Argentina.

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
|May 29, 2016
PubMed
Abstract

Insights

Fusarium species infections are uncommon in pediatric burn patients, primarily affecting the burn wound. While mortality is low, prompt antifungal treatment is crucial for recovery.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pediatric Burn Care

Background:

  • Fusarium species are opportunistic fungi causing infections, particularly severe ones in burn patients.
  • Literature on Fusarium infections in pediatric burn patients is limited.
  • This study addresses the scarcity of data on Fusarium infections in this vulnerable population.

Purpose of the Study:

  • To detail the clinical and epidemiological characteristics of Fusarium infections in pediatric burn patients.
  • To evaluate the outcomes of these infections.
  • To contribute to understanding Fusarium spp. as a pathogen in pediatric burn care.

Main Methods:

  • Retrospective, descriptive study design.
  • Inclusion of pediatric patients treated in a specialized intensive care burn unit.
  • Analysis of clinical data, epidemiological features, and treatment outcomes.

Main Results:

  • Fifteen pediatric patients diagnosed with Fusarium infections.
  • Median age of 48 months; ten with direct fire injury, median burn surface area of 45%, twelve with full thickness burns.
  • Fungal infection occurred at a median of 11 days post-burn; burn wound was the most common isolation site (14/15 patients).
  • Amphotericin B and voriconazole were primary treatments; median treatment duration was 23 days.
  • One patient (7%) experienced mortality attributed to fungal infection.

Conclusions:

  • Fusarium species are infrequent pathogens in severely burned pediatric patients.
  • The burn wound is the predominant site for Fusarium infections.
  • Low mortality rates observed in this cohort, highlighting the importance of timely antifungal intervention.
Keywords:
BurnFungal infectionsFusarium spp

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