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Related Concept Videos

Epigenetic Regulation01:37

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Related Experiment Video

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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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Distributional changes in gene-specific methylation associated with temperature.

Marie-Abele C Bind1, Brent A Coull2, Andrea Baccarelli3

  • 1Department of Statistics, Faculty of Arts and Science, Harvard University, Cambridge, MA, USA.

Environmental Research
|May 30, 2016
PubMed
Summary
This summary is machine-generated.

Temperature influences DNA methylation differently across its distribution. Some individuals, particularly those with lower F3, TLR-2, CRAT, and iNOS methylation, may be more susceptible to temperature-related inflammation.

Keywords:
DNA methylationQuantile regressionSusceptibilityTemperature

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Area of Science:

  • Environmental Epigenetics
  • Human Health
  • Aging Research

Background:

  • Temperature is linked to average DNA methylation changes.
  • Associations between temperature and DNA methylation may vary across the full range of methylation levels.

Purpose of the Study:

  • To investigate if temperature's association with DNA methylation differs across quantiles of methylation distributions.
  • To examine nine candidate genes in elderly men using longitudinal data.

Main Methods:

  • Quantile regression for longitudinal data was employed.
  • Gene-specific blood methylation (%5mC) was measured repeatedly in 777 elderly men (Normative Aging Study, 1999-2010).
  • Associations between three-week averaged temperature and methylation were analyzed across methylation distribution percentiles.

Main Results:

  • Heterogeneity in temperature-methylation associations was observed across methylation percentiles for F3, TLR-2, CRAT, iNOS, and ICAM-1 genes.
  • Increased temperature exposure correlated with decreased methylation at lower quantiles (e.g., 20th percentile) for F3, but not significantly at higher quantiles (e.g., 80th percentile).
  • Specific methylation levels in F3, TLR-2, CRAT, and iNOS (low values) and ICAM-1 (high values) indicate heightened susceptibility to temperature's effects on systemic inflammation.

Conclusions:

  • Temperature's impact on DNA methylation is not uniform and varies depending on an individual's methylation level.
  • Certain individuals, characterized by specific methylation profiles in candidate genes, are more vulnerable to environmental temperature changes impacting systemic inflammation.