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A double responsive smart upconversion fluorescence sensing material for glycoprotein.

Ting Guo1, Qiliang Deng1, Guozhen Fang1

  • 1Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China.

Biosensors & Bioelectronics
|May 30, 2016
PubMed
Summary
This summary is machine-generated.

A new smart material using upconversion nanoparticles offers highly specific glycoprotein detection. This double-responsive material enables precise sensing and enrichment of target glycoproteins by adjusting pH and temperature.

Keywords:
GlycoproteinGraphene oxideMolecular imprintingSmart materialUpconversion nanoparticles

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Glycoproteins play crucial roles in various biological processes.
  • Accurate detection and enrichment of glycoproteins are essential for disease diagnosis and drug development.
  • Existing methods for glycoprotein analysis often face challenges in specificity and sensitivity.

Purpose of the Study:

  • To develop a novel double-responsive smart upconversion fluorescence material.
  • To achieve highly specific enrichment and sensing of glycoproteins.
  • To explore the material's responsiveness to environmental stimuli like pH and temperature.

Main Methods:

  • Synthesis of a smart sensing material incorporating graphene oxide (GO), upconversion nanoparticles (UCNPs), and functional monomers (NIPAAM, VPBA).
  • Characterization of the material's structure and composition using TEM, SEM, XPS, and FTIR.
  • Evaluation of the material's recognition capabilities for proteins and glycoproteins, including selectivity and response to stimuli.

Main Results:

  • Successful synthesis and characterization of the double-responsive smart sensing material.
  • Demonstrated gradual decrease in fluorescence intensity with increasing protein concentration.
  • Exhibited selective recognition of Horse radish peroxidase (HRP) among other proteins.
  • Showcased tunable recognition ability for glycoproteins by controlling pH and temperature.

Conclusions:

  • The developed strategy provides a novel approach for constructing smart materials.
  • The smart sensing material demonstrates high specificity and sensitivity for glycoprotein detection.
  • This work opens new avenues for advanced glycoprotein analysis and diagnostics.