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Interactions between Pseudomonas aeruginosa and Staphylococcus aureus during co-cultivations and polymicrobial

Angela T Nguyen1, Amanda G Oglesby-Sherrouse2,3

  • 1School of Pharmacy, Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, 21201, USA.

Applied Microbiology and Biotechnology
|May 30, 2016
PubMed

Insights

Interactions between Pseudomonas aeruginosa and Staphylococcus aureus can enhance infection virulence. This review explores how these bacterial pathogens interact and impact host environments and treatments.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Bacterial Pathogenesis

Background:

  • Pseudomonas aeruginosa and Staphylococcus aureus are key pathogens in polymicrobial infections.
  • Interactions between these bacteria range from parasitic to mutualistic, often increasing overall virulence.
  • Host environment significantly influences these interactions, affecting disease and treatment.

Purpose of the Study:

  • To review the impact of Pseudomonas aeruginosa and Staphylococcus aureus interactions on hosts and pathogens.
  • To elucidate the molecular mechanisms driving these inter-bacterial interactions.
  • To examine host-specific factors influencing these pathogen dynamics.

Main Methods:

  • Literature review of studies on Pseudomonas aeruginosa and Staphylococcus aureus interactions.
  • Analysis of research on molecular mechanisms of bacterial cooperation and competition.
  • Synthesis of findings on host-pathogen interactions in polymicrobial settings.

Main Results:

  • Bacterial interactions significantly modulate virulence and disease progression.
  • Specific molecular pathways govern the interplay between these pathogens.
  • Host factors critically shape the outcome of polymicrobial infections.

Conclusions:

  • Understanding Pseudomonas aeruginosa and Staphylococcus aureus interactions is crucial for developing effective therapies.
  • Host-specific factors are key determinants in polymicrobial infection outcomes.
  • Further research into molecular mechanisms can reveal novel therapeutic targets.
Keywords:
Alkyl-quinolonesCystic fibrosisPolymicrobial infectionsPseudomonas aeruginosaStaphylococcus aureus

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