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The influence of intensive lifestyle intervention on patients with isolated impaired fasting glucose: a meta-analysis
Xiu-Juan Yang1, Shu-Fang Zou2, Yong Xu3
1Southwest Medical University School of Nursing, Luzhou, China.
Aim:
To evaluate the effect of intensive lifestyle intervention on patients with isolated impaired fasting glucose.
Background:
The application of lifestyle intervention to clinical nursing can help improve outcomes of patients with impaired fasting glucose.
Design:
We performed a meta-analysis of randomized controlled trials using methods outlined in the Cochrane Handbook.
Methods:
We performed keyword searches of the literature databases up to September 2014 and performed manual searches of selected article reference lists. Data were extracted by the lead reviewer, cross-checked by the second reviewer, entered into RevMan5·3, and pooled and analysed using the fixed effect inverse-variance model or random effects model to determine the mean difference and calculate the weighted mean difference. The heterogeneity statistic (I2 ), overall effect (Z) and P-value were calculated.
Results:
A total of five studies were included in our analysis. Following the heterogeneity test statistic, overall effect Z score with P-value was calculated. The targets of fasting plasma glucose, weight, body mass index, triglycerides, high-density lipoprotein cholesterol and total cholesterol all showed significant differences between the intervention and control groups.
Conclusion:
Lifestyle intervention can improve glycaemic control in patients with isolated impaired fasting glucose. It also reduces blood-lipid levels and promotes weight loss. Larger patient cohorts and adequate follow-up should be included in future trials.
