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Published on: August 30, 2018
Antibiotic consumption in Turkish hospitals; a multi-centre point prevalence study
Ertugrul Guclu1, Aziz Ogutlu1, Oguz Karabay1
1a Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology , Sakarya University , Sakarya , Turkey.
Abstract:
This multi-centre study aimed to determine the antibiotic consumption in Turkish hospitals by point prevalence. Antibiotic consumption of 14 centres was determined using the DDD method. Among hospitalized patients, 44.8% were using antibiotics and the total antibiotic consumption was 674.5 DDD/1000 patient-days (DPD). 189.6 (28%) DPD of the antibiotic consumption was restricted while 484.9 (72%) DPD was unrestricted. Carbapenems (24%) and beta lactam/beta lactamase inhibitors (ampicillin-sulbactam or amoxicillin-clavulanate; 22%) were the most commonly used restricted and unrestricted antibiotics. Antibiotics were most commonly used in intensive care units (1307.7 DPD). Almost half of the hospitalized patients in our hospitals were using at least one antibiotic. Moreover, among these antibiotics, the most commonly used ones were carbapenems, quinolones and cephalosporins, which are known to cause collateral damage. We think that antibiotic resistance, which is seen at considerably high rates in our hospitals, is associated with this level of consumption.
Insights
Turkish hospitals show high antibiotic use, with nearly half of patients receiving them. Carbapenems and beta-lactam/beta-lactamase inhibitors were most common, potentially fueling antibiotic resistance.
Area of Science:
- Infectious Diseases
- Pharmacology
- Public Health
Background:
- Antibiotic consumption is a key factor influencing antimicrobial resistance.
- Understanding antibiotic usage patterns is crucial for developing effective stewardship programs.
Purpose of the Study:
- To determine the point prevalence of antibiotic consumption in Turkish hospitals.
- To identify the most frequently used antibiotic classes and their usage patterns.
Main Methods:
- A multi-centre point prevalence study was conducted across 14 Turkish hospitals.
- Antibiotic consumption was measured using the Defined Daily Dose (DDD) method, expressed as DDD per 1000 patient-days (DPD).
Main Results:
- 44.8% of hospitalized patients were using antibiotics, with a total consumption of 674.5 DPD.
- Unrestricted antibiotic use (72%) significantly exceeded restricted use (28%).
- Carbapenems (24%) and beta-lactam/beta-lactamase inhibitors (22%) were the most common restricted and unrestricted antibiotics, respectively. Intensive care units showed the highest consumption (1307.7 DPD).
Conclusions:
- High antibiotic consumption, particularly of broad-spectrum agents like carbapenems, is prevalent in Turkish hospitals.
- The findings suggest a potential association between high antibiotic consumption and elevated rates of antibiotic resistance observed in these facilities.
- Implementation of antibiotic stewardship interventions is warranted to optimize antibiotic use and combat resistance.
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