Familial florid osseous dysplasia: a case report

Area of Science:

• Oral and Maxillofacial Pathology
• Dental Radiology
• Bone Biology

Background:

• Florid osseous dysplasia (FOD) is a fibro-osseous lesion often discovered incidentally during routine dental radiographic examinations.
• Its radiographic appearance can mimic other benign fibro-osseous lesions, complicating definitive diagnosis.
• Histological similarities among various benign fibro-osseous lesions necessitate comprehensive clinical and radiographic data for accurate diagnosis.

Observation:

• The radiographic progression of FOD involves a transition from a radiolucent to a radiopaque state as bone sclerosis increases.
• Dense bone in FOD cases exhibits significant susceptibility to secondary infections, such as osteomyelitis, especially with age and trauma.
• While often self-limiting, FOD can manifest as a persistent, symptomatic condition throughout a patient's life.

Findings:

• The diagnostic and treatment pathway for symptomatic florid osseous dysplasia presents a clinical dilemma.
• A known predilection exists for Black women, though further research is needed.
• The potential for familial clustering in individuals of Italian descent requires additional case evaluations to confirm inheritance patterns.

Implications:

• Accurate differentiation of florid osseous dysplasia from other fibro-osseous lesions is crucial for appropriate management.
• Awareness of infection susceptibility in FOD is vital for preventative strategies and timely treatment.
• Further research into the epidemiology and genetics of florid osseous dysplasia may refine diagnostic criteria and treatment approaches.