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[A study on the mechanism of phleboid olfactory function].

E Okabe

    Nihon Jibiinkoka Gakkai Kaiho
    |January 1, 1989
    PubMed
    Summary

    Intravenous Alinamin infusion allows smell perception through exhalation, not other routes. This clarifies the mechanism of olfactory response to Alinamin byproducts.

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    Area of Science:

    • Olfactory Neuroscience
    • Pharmacology

    Background:

    • The phleboid olfactory test is clinically significant for olfactory disturbances.
    • The precise mechanism of smell perception following intravenous Alinamin infusion remains unclear.
    • A proposed mechanism involves Alinamin byproducts reaching the nasal cavity via exhalation.

    Purpose of the Study:

    • To elucidate the olfactory mechanism after intravenous Alinamin infusion.
    • To investigate the role of exhalation in Alinamin-induced smell perception.

    Main Methods:

    • Examined olfactory response to Alinamin in laryngectomy patients.
    • Analyzed saliva for odorous substances before and after Alinamin infusion in healthy subjects.
    • Assessed garlic odor perception in healthy subjects with inhibited smell after Alinamin infusion.

    Main Results:

    • Laryngectomy patients without nasal cotton (80%) and with nasal cotton (20%) perceived garlic odor.
    • No garlic odorous substance was detected in saliva samples.
    • Subjects with inhibited smell perceived garlic odor concurrently with exhalation post-Alinamin infusion.

    Conclusions:

    • Intravenous Alinamin facilitates smell perception primarily through exhalation.
    • The olfactory pathway is not influenced by saliva or direct nasal routes in this context.

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