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08:56
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
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Relation between bile acids and myocardial damage in obstructive jaundice.
1Yi-Ping Mu, Shu-You Peng, Department of Surgery, Second Affiliated Hospital, Zhejiang Medical University, Hangzhou 310009, Zhejiang Province, China.
World Journal of Gastroenterology
|May 31, 2016
Summary
Obstructive jaundice causes myocardial damage due to increased serum bile acids. This study shows elevated bile acids directly harm heart mitochondria, confirming their role in cardiac dysfunction during bile duct obstruction.
Area of Science:
- Cardiology
- Hepatology
- Toxicology
Background:
- Obstructive jaundice is associated with cardiac complications.
- The precise mechanisms linking bile duct obstruction to heart damage are not fully understood.
Purpose of the Study:
- To investigate myocardial morphologic changes in obstructive jaundice.
- To determine the relationship between serum bile acids and cardiac alterations.
Main Methods:
- Rats underwent common bile duct ligation (BDL) for one or two weeks, or sham operation (SO).
- Myocardial morphology and total serum bile acid (TBA) levels were assessed.
- Rats were also administered sodium cholate to mimic jaundice-induced TBA levels.
Main Results:
- Common bile duct ligation led to significant increases in serum TBA and myocardial mitochondrial damage.
- Exogenous sodium cholate administration, mimicking elevated TBA levels, induced similar myocardial damage.
Conclusions:
- Increased endogenous bile acids are a causative factor in myocardial damage during obstructive jaundice.
- Elevated serum bile acids directly contribute to cardiac mitochondrial injury.
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