Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

28.3K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
28.3K
Telomeres and Telomerase02:41

Telomeres and Telomerase

7.9K
7.9K
Histone Variants at the Centromere02:30

Histone Variants at the Centromere

5.2K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.2K
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

2.8K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.8K
Condensins02:15

Condensins

4.8K
Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
4.8K
Condensins02:15

Condensins

2.2K
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Addendum: Telomouse-a mouse model with human-length telomeres generated by a single amino acid change in RTEL1.

Nature communications·2026
Same author

Identification of ADAR1i-124: The first effective A-to-I RNA editing inhibitor with promising cancer therapeutic potential.

iScience·2026
Same author

Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1.

Nucleic acids research·2025
Same author

Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers.

Journal of medicinal chemistry·2025
Same author

Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders.

Journal of medicinal chemistry·2024
Same author

Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1.

bioRxiv : the preprint server for biology·2024
Same journal

Experimental and Mechanistic Validation of PARP1pred for Identifying Potent Leads.

Computational and structural biotechnology journal·2026
Same journal

DepMicroDiff: Diffusion-Based Dependency-Aware Multimodal Imputation for Microbiome Data.

Computational and structural biotechnology journal·2026
Same journal

Simulating Multicolor Super-Resolution Imaging Using an RGB Camera.

Computational and structural biotechnology journal·2026
Same journal

MetaphorPrompt2-A Structure and Function-Focused Approach for Extracting Causal Events from Biological Text.

Computational and structural biotechnology journal·2026
Same journal

Microbiome-Metabolome Crosstalk in HPV Pathogenesis: From Ecosystem Dynamics to Translational Biomarkers.

Computational and structural biotechnology journal·2026
Same journal

Minimum-Cost Synthetic Genome Planning: An Algorithmic Framework.

Computational and structural biotechnology journal·2026
See all related articles

Related Experiment Video

Updated: Mar 20, 2026

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
11:21

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions

Published on: August 30, 2024

1.4K

Structure and function of the telomeric CST complex.

Cory Rice1, Emmanuel Skordalakes1

  • 1The Wistar Institute, and the Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia PA 19104, USA.

Computational and Structural Biotechnology Journal
|May 31, 2016
PubMed
Summary
This summary is machine-generated.

The CST complex is crucial for maintaining telomeres, essential for cell proliferation and genome stability across diverse organisms. It regulates access to telomeres, ensuring proper DNA replication and capping.

More Related Videos

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
05:35

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins

Published on: March 3, 2016

15.8K
In vitro Reconstitution of the Active T. castaneum Telomerase
09:25

In vitro Reconstitution of the Active T. castaneum Telomerase

Published on: July 14, 2011

12.1K

Related Experiment Videos

Last Updated: Mar 20, 2026

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
11:21

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions

Published on: August 30, 2024

1.4K
Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
05:35

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins

Published on: March 3, 2016

15.8K
In vitro Reconstitution of the Active T. castaneum Telomerase
09:25

In vitro Reconstitution of the Active T. castaneum Telomerase

Published on: July 14, 2011

12.1K

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Telomeres protect eukaryotic chromosome ends and are vital for cell division and genome integrity.
  • Telomere replication and maintenance involve telomerase and protein complexes like shelterin and CST (Cdc13/Ctc1, Stn1, Ten1).

Purpose of the Study:

  • To review the diverse functions of the CST complex in telomere maintenance.
  • To highlight the conserved and organism-specific roles of CST in genome stability and cell proliferation.

Main Methods:

  • Literature review focusing on the CST complex and its interactions.
  • Analysis of CST's roles in telomere capping and regulation of telomerase and DNA polymerase alpha-primase access.

Main Results:

  • The CST complex is conserved across many organisms, not just yeast.
  • CST participates in telomere capping and regulates access of key enzymes to telomeres.
  • CST functions are coordinated with the shelterin complex.

Conclusions:

  • The CST complex plays a fundamental and diverse role in telomere maintenance and cell proliferation.
  • Understanding CST's functions is key to comprehending genome stability mechanisms.