Susceptibility of inbred mice to Paragonimus miyazakii infection
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Published on: November 6, 2019
Abstract:
Differences in the susceptibility among inbred strains of mice to Paragonimus miyazakii infection were examined. Recovery of worms varied among the strains used. More were recovered from BALB/c mice than from any of the other strains; whereas, the fewest were recovered from C57BL/6 and C57BL/10. No worm formed a cyst in the lung or matured in any of the strains.
Insights
Mouse strain differences impact Paragonimus miyazakii infection susceptibility. BALB/c mice showed higher worm recovery, while C57BL strains had the lowest, though no worms matured in any group.
Area of Science:
- Parasitology
- Immunology
- Genetics
Background:
- Paragonimus miyazakii is a lung fluke parasite.
- Inbred mouse strains exhibit varying immune responses.
- Understanding host susceptibility is crucial for parasite control.
Purpose of the Study:
- To investigate differential susceptibility of inbred mouse strains to Paragonimus miyazakii infection.
- To quantify worm recovery across various mouse genetic backgrounds.
Main Methods:
- Infection of multiple inbred mouse strains with Paragonimus miyazakii metacercariae.
- Post-infection assessment of worm burden and recovery rates.
- Gross examination of lungs for cyst and worm development.
Main Results:
- Significant variation in Paragonimus miyazakii worm recovery was observed among different inbred mouse strains.
- BALB/c mice demonstrated the highest worm recovery.
- C57BL/6 and C57BL/10 strains exhibited the lowest worm recovery.
Conclusions:
- Inbred mouse strain genetics significantly influence susceptibility to Paragonimus miyazakii infection.
- BALB/c mice are more permissive hosts compared to C57BL/6 and C57BL/10 strains.
- No evidence of successful parasite maturation or cyst formation was found in any strain under study conditions.
