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Related Experiment Videos

Electrogenic sodium transport in the developing rabbit cecum.

G D Potter1, S M Burlingame, E J Cragoe

  • 1Department of Medicine, University of Texas Medical School, Houston 77225.

Journal of Pediatric Gastroenterology and Nutrition
|May 1, 1989
PubMed
Summary

Newborn rabbit cecum shows limited sodium absorption. This electrogenic sodium transport develops significantly after four weeks of life, becoming responsive to phenamil.

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Area of Science:

  • Physiology
  • Developmental Biology
  • Gastrointestinal Science

Background:

  • Adult rabbit cecum exhibits electrogenic, chloride-independent sodium absorption, inhibited by phenamil.
  • This specific sodium transport mechanism is unique to the cecum in adult rabbits.

Purpose of the Study:

  • To investigate the developmental changes in electrogenic sodium transport in the newborn rabbit cecum.
  • To determine the age at which this transport system matures and becomes phenamil-sensitive.

Main Methods:

  • Cecal tissues from rabbits aged 7 to 38 days were studied using Ussing chambers.
  • Measurements included sodium (Na) and chloride (Cl) flux and short-circuit current (Isc).
  • The effect of phenamil on sodium transport was assessed at different developmental stages.

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Main Results:

  • Short-circuit current (Isc) and net sodium transport (JNanet) significantly increased from 7-10 days to 35-38 days of age.
  • Electrogenic sodium absorption was not inhibited by phenamil in 7-10 day old rabbits.
  • By 35-38 days, phenamil significantly reduced JNanet, indicating the development of a phenamil-sensitive transport system.

Conclusions:

  • The rabbit cecum does not exhibit significant electrogenic sodium absorption until after the fourth week of life.
  • The development of this transport system is characterized by a gradual increase in sodium absorption and the emergence of phenamil sensitivity.