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Eyelid Metastatic Thyroid Papillary Carcinoma.
Hardeep Singh Mudhar1, Murtuza Nuruddin2, Soma Rani Roy2
1National Specialist Ophthalmic Pathology Service (NSOPS), Department of Histopathology, E-Floor, Royal Hallamshire Hospital, Sheffield, UK.
Ocular Oncology and Pathology
|May 31, 2016
Summary
This study reports the first case of eyelid metastasis from papillary thyroid carcinoma presenting as an eyelid mass. This rare presentation highlights the importance of considering metastatic disease in eyelid lesions.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Eyelid metastases are rare, often presenting as a diagnostic challenge.
- Metastatic disease to the eyelid can mimic primary adnexal tumors or lymphomas.
Observation:
- A 70-year-old male presented with a 6-month history of a painless, hard, red nodular growth in the left lower eyelid.
- The lesion involved the eyelid's anterior and posterior lamella, including the canaliculus and punctum.
Findings:
- Histopathological and immunohistochemical analysis revealed metastatic papillary thyroid carcinoma.
- Tumor cells showed characteristic features including optically clear nuclei, nuclear grooves, and positivity for thyroid transcription factor-1 and thyroglobulin.
Implications:
- This case represents the first documented instance of papillary thyroid carcinoma presenting as an eyelid metastasis.
- The findings underscore the necessity of a thorough systemic evaluation for patients with eyelid masses, even in the absence of a known thyroid primary.
