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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Mar 20, 2026

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

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Published on: September 4, 2021

Optic Nerve Assessment Using 7-Tesla Magnetic Resonance Imaging.

Arun D Singh¹, Sean M Platt¹, Lisa Lystad¹

¹Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Ocular Oncology and Pathology

|May 31, 2016

Summary

High-resolution 7-tesla MRI successfully detected optic nerve invasion in choroidal melanoma, a finding missed by other imaging methods. This advanced imaging is crucial for treatment decisions like enucleation.

Keywords:

7-tesla magnetic resonance imaging Choroidal malignant melanoma Optic nerve

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Area of Science:

Ophthalmology
Radiology
Oncology

Background:

Juxtapapillary choroidal melanoma can invade the optic nerve, impacting treatment strategies.
Accurate detection of optic nerve invasion is critical for patient management.

Observation:

Standard imaging techniques (OCT, ultrasound, 1.5T MRI) failed to identify optic nerve invasion.
A 7-tesla MRI of an enucleated eye precisely identified optic nerve invasion.

Findings:

Ex vivo 7-tesla MRI correlated with histopathologic findings of optic nerve invasion.
Lower-resolution imaging modalities were insufficient for detecting this invasion.

Implications:

7-tesla MRI shows potential for diagnosing optic nerve invasion in intraocular tumors.
Accurate diagnosis influences surgical decisions, including enucleation.