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Radiopaque hydrogel microspheres.

B C Thanoo1, A Jayakrishnan

  • 1Division of Polymer Chemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.

Journal of Microencapsulation
|April 1, 1989
PubMed
Summary
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Researchers developed radiopaque poly(methyl methacrylate) microspheres for medical imaging. These barium sulfate-impregnated particles show excellent X-ray contrast, suitable for endovascular embolization procedures.

Area of Science:

  • Biomaterials Science
  • Radiology
  • Polymer Chemistry

Background:

  • Poly(methyl methacrylate) (PMMA) microspheres are used in medical applications.
  • Developing radiopaque materials is crucial for medical imaging and procedures.
  • Endovascular embolization requires effective contrast agents.

Purpose of the Study:

  • To create radiopaque, hydrophilic microspheres from crosslinked PMMA.
  • To evaluate the potential of these microspheres as particulate emboli for endovascular embolization.

Main Methods:

  • Synthesized spherical, hydrophilic PMMA microspheres via alkaline hydrolysis.
  • Impregnated microspheres with barium sulfate using a precipitation technique.
  • Controlled microsphere swelling and barium sulfate entrapment through acidification and anhydride formation.

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Main Results:

  • Achieved high barium sulfate loading (up to 70 wt-per cent).
  • Demonstrated excellent X-ray contrast properties of the prepared microspheres.
  • Successfully trapped barium sulfate firmly within the microspheres.

Conclusions:

  • The developed PMMA microspheres exhibit superior radiopacity.
  • These microspheres are promising for use as particulate emboli in endovascular embolization.
  • The controlled swelling and entrapment technique ensures stable radiopaque material.