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[Peripheral vessel wall changes in hypertensive patients with gout]

B A Shelest1

  • 1Kharkov National Medical University, Kharkov, Ukraine.

Terapevticheskii Arkhiv
|May 31, 2016
PubMed

Insights

Hypertension with gout significantly worsens arterial stiffness and endothelial dysfunction, indicating an early atheromatous process. Elevated pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI) predict a poorer hypertension prognosis.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Rheumatology

Background:

  • Hypertension and gout are prevalent conditions often co-existing.
  • Endothelial dysfunction and arterial stiffness are key factors in cardiovascular disease progression.

Purpose of the Study:

  • To investigate arterial wall endothelial dysfunction and stiffness in hypertensive patients with concurrent gout.
  • To compare these features between hypertensive patients with and without gout.

Main Methods:

  • 54 hypertensive patients were divided into groups with (n=33) and without (n=21) gout/hyperuricemia.
  • Assessed: intima-media thickness (IMT), pulse wave velocity (PWV), cardio-ankle vascular index (CAVI), endothelin-1 (ET-1), and endothelium-dependent vasodilation (EDVD).

Main Results:

  • Hypertension with gout showed significant arterial structural changes, suggesting early atheromatous processes.
  • Gout exacerbates endothelial dysfunction and worsens hypertension outcomes.
  • Elevated PWV, CAVI, and ET-1 levels correlated with a poorer prognosis.

Conclusions:

  • Arterial stiffness indices (CAVI, PWV) and ET-1 levels are critical indicators of cardiovascular risk in hypertensive patients.
  • IMT and EDVD provide additional criteria for cardiovascular risk assessment in this population.
Abstract

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