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Increased Frequency of Th17 Cells in Children With Mycoplasma pneumoniae Pneumonia

Xiaowei Wang1, Xiaojun Chen2, Heng Tang3

  • 1Department of Blood Transfusion, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, China.

Journal of Clinical Laboratory Analysis
|May 31, 2016
PubMed
Abstract

Insights

Th17 cells are elevated in children with Mycoplasma pneumoniae infection, particularly those with extrapulmonary issues. These immune cells may aid in clearing the infection but could also cause damage in persistent cases.

Area of Science:

  • Immunology
  • Pediatrics
  • Infectious Diseases

Background:

  • Mycoplasma pneumoniae causes atypical pneumonia, especially in children.
  • Host immune responses are crucial in M. pneumoniae pathogenesis.
  • The role of Th17 cells in M. pneumoniae infection is not well understood.

Purpose of the Study:

  • To investigate the role of Th17 cells in pediatric M. pneumoniae infections.
  • To determine if Th17 cell frequency correlates with disease severity or manifestations.

Main Methods:

  • Flow cytometry was used to measure T cell, CD4+ T cell, and Th17 cell percentages.
  • Analysis was conducted on children diagnosed with M. pneumoniae infection.

Main Results:

  • Children with M. pneumoniae infection showed increased Th17 cell frequency.
  • Higher Th17 cell percentages were observed in infected children with extrapulmonary manifestations.
  • An increase in Th17 cells was noted in patients with short-course Mycoplasma pneumoniae pneumonia (MPP).

Conclusions:

  • Th17 cells likely contribute to clearing M. pneumoniae during acute infection.
  • Excessive Th17 cell responses may lead to immunopathological damage in persistent infections.
Keywords:
Mycoplasma PneumoniaeTh17 cellschildrenrespiratory infection

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