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Related Experiment Video

Updated: Mar 20, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Microbiome and its impact on gastrointestinal atopy.

A B Muir^1,2, A J Benitez³, K Dods¹

¹Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

|May 31, 2016

Summary

The gut microbiome influences allergic diseases like asthma and food allergies. Understanding its role may help treat eosinophilic gastrointestinal diseases (EGIDs), such as eosinophilic esophagitis (EoE).

Keywords:

asthma atopic dermatitis bacteria eosinophil eosinophilic esophagitis

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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Area of Science:

Immunology
Microbiology
Gastroenterology

Background:

Allergic conditions are rising in Westernized nations.
Gut microbiome dysbiosis is implicated in allergic disease development.
Factors like genetics, environment, and diet impact gut microbiota and immune homeostasis.

Purpose of the Study:

To review the role of the gut microbiome in atopic conditions.
To explore the development of immune tolerance from molecular and clinical perspectives.
To investigate the potential application of this knowledge to eosinophilic gastrointestinal diseases (EGIDs), particularly eosinophilic esophagitis (EoE).

Main Methods:

Literature review of murine and human studies.
Analysis of molecular and clinical data on immune tolerance.
Examination of gut microbiome's role in atopic diseases.

Main Results:

Studies confirm the microbiota's role in asthma, atopic dermatitis, and food allergies.
The microbiome's function in EGIDs remains largely unknown.
Current research focuses on understanding tolerance mechanisms.

Conclusions:

The gut microbiome is crucial in allergic disease pathogenesis.
Further research is needed to elucidate the microbiome's role in EGIDs.
Knowledge of the microbiome may lead to novel strategies for EGID prevention and treatment.