Externally controlled drug release using a gold nanorod contained composite membrane
Kibeom Kim1, Min-Chul Jo2, Sundo Jeong2
1Department of Chemistry, Sahmyook University, Seoul, 01795, Korea. mpark@syu.ac.kr and Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, 44919, Korea. jhryu@unist.ac.kr.
Nanoscale
|June 1, 2016
Summary
This study presents a novel light-triggered drug delivery system using gold nanorods and dendrimers for on-demand pulsatile release. The system offers enhanced therapeutic efficacy and reduced side effects for personalized medicine.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Materials Science
Background:
- Current drug delivery systems face challenges in precise therapeutic control and minimizing side effects.
- On-demand drug release mechanisms are crucial for personalized medicine and complex treatment strategies.
Purpose of the Study:
- To develop and validate a versatile, light-triggered drug delivery device for on-demand pulsatile therapeutic release.
- To investigate the correlation between near-infrared (NIR) laser parameters and drug release kinetics.
- To assess the potential for multi-drug delivery strategies with controlled release profiles.
Main Methods:
- Fabrication of nanoporous membranes incorporating gold nanorods and dendrimers.
- Utilizing near-infrared (NIR) laser irradiation to trigger drug release.
- In vitro experiments to confirm biocompatibility and drug release control.
- Analysis of drug release rates under varying laser energy and temperature conditions.
Main Results:
- Demonstrated light-triggered, on-demand pulsatile release of highly enriched therapeutics.
- Established a direct correlation between NIR laser energy, temperature increase, and drug release rate.
- Confirmed biocompatibility and versatile drug release control in both static and fluidic systems.
- Observed distinct drug responses to NIR stimuli, indicating potential for multi-drug delivery.
Conclusions:
- The developed nanoporous membrane system offers a biocompatible platform for precise, on-demand drug delivery.
- NIR light-triggered release provides a versatile strategy for personalized therapies requiring multi-drug administration.
- This enhanced delivery system promises improved therapeutic efficacy and reduced side effects through regulated plasma drug profiles.
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