Steroid Hormone Receptor Coregulators in Endocrine Cancers

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Jean-Pierre Obeid1, Nawal Zafar1, Jimmy El Hokayem1

  • 1Department of Biochemistry and Molecular Biology, University of Miami, FL, USA.

IUBMB Life
|June 1, 2016
PubMed

Insights

Transcriptional coregulators are key players in endocrine cancers, influencing gene expression through interactions with steroid hormone receptors. This review details coregulator classes, their mechanisms, and therapeutic potential in hormone-responsive cancers.

Area of Science:

  • Molecular Biology
  • Endocrinology
  • Cancer Research

Background:

  • Coregulators dynamically modulate cellular transcriptional activity.
  • Steroid hormone receptors (SHRs) are pivotal in endocrine cancers, interacting with coregulators to alter gene expression.
  • Coregulator families are implicated in the development, progression, and invasion of hormone-responsive cancers.

Purpose of the Study:

  • To review different classes of coregulators involved in endocrine cancers.
  • To highlight unique information regarding each coregulator family.
  • To discuss mechanisms, interventions, and novel research directions for coregulators in endocrine cancers.

Main Methods:

  • This mini-review synthesizes existing literature on coregulators in endocrine cancers.
  • It focuses on the roles of various coregulator families.
  • Information is presented regarding mechanisms, therapeutic interventions, and future research avenues.

Main Results:

  • Coregulators exhibit diverse roles in transcriptional regulation within endocrine cancers.
  • Specific coregulator families have distinct implications in cancer development and progression.
  • Understanding these interactions offers potential for novel therapeutic strategies.

Conclusions:

  • Coregulators are critical modulators of gene expression in endocrine cancers.
  • Targeting coregulator pathways presents a promising avenue for cancer intervention.
  • Further research into coregulator mechanisms and novel directions is essential for advancing treatment.
Keywords:
coregulatorendocrine cancerhormonenuclear receptorssteroid hormone receptortranscriptional regulation

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