Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

3.0K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
3.0K
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

86
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
86
Classification of Neurotransmitters01:30

Classification of Neurotransmitters

5.8K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
5.8K
Seizures: Classification01:13

Seizures: Classification

2.0K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
2.0K
Genetic Lingo01:11

Genetic Lingo

117.1K
Overview
117.1K
Pedigree Analysis01:35

Pedigree Analysis

90.5K
Overview
90.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary Lateral Sclerosis French National Diagnostic and Care Protocol.

Revue neurologique·2026
Same author

Treatment pathway, healthcare resource utilization and direct cost of ALS in France: A nationwide claims database study.

Revue neurologique·2026
Same author

Prevalence of SOD1 and C9orf72 Variants Among French ALS Population: The GENIALS Study.

European journal of neurology·2025
Same author

French guidelines for the diagnosis and management of pure hereditary spastic paraplegia.

Revue neurologique·2025
Same author

The safety of COVID-19 vaccines in a large French series of patients with neuromuscular conditions and the impacts of vaccination on their daily lives.

Revue neurologique·2025
Same author

New double homozygous GDAP1 variations associated with polyneuropathy and prominent inflammatory features in unrelated individuals from Indian Ocean islands.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025

Related Experiment Video

Updated: Mar 20, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.7K

Classifications of neurogenetic diseases: An increasingly complex problem.

J-M Vallat1, C Goizet2, M Tazir3

  • 1Service de neurologie, centre de référence « neuropathies périphériques rares », CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France.

Revue Neurologique
|June 1, 2016
PubMed
Summary

Genetic discoveries in neurodegenerative disorders complicate classification. This study proposes updated, simplified classifications for several hereditary neurological conditions, aiding diagnosis and research.

Keywords:
Cerebellar ataxiaCharcot–Marie–ToothClassificationHSANSpastic paraplegia

More Related Videos

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.6K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

9.2K

Related Experiment Videos

Last Updated: Mar 20, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.7K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.6K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

9.2K

Area of Science:

  • Neurology
  • Genetics
  • Molecular Biology

Background:

  • Neurodegenerative disorders affect the central and peripheral nervous systems.
  • While many were described historically, recent genetic discoveries have complicated their classification.
  • Ongoing identification of disease-causing mutations necessitates a re-evaluation of existing categories.

Purpose of the Study:

  • To propose updated and simplified classifications for specific neurodegenerative disorders.
  • To address the challenges posed by new genetic findings in disease categorization.
  • To facilitate clearer understanding and diagnosis of hereditary neurological conditions.

Main Methods:

  • Review of current genetic data and disease classifications.
  • Comparative analysis of mutation discovery trends.
  • Development of revised classification frameworks.

Main Results:

  • Identification of key genetic drivers for specific neurodegenerative conditions.
  • Proposal of a streamlined classification system for affected diseases.
  • Demonstration of how updated classifications accommodate recent genetic knowledge.

Conclusions:

  • A simplified classification system is crucial for navigating the complexities of neurodegenerative disorders.
  • Updated classifications based on genetic findings improve diagnostic accuracy.
  • This work provides a foundation for future research and clinical management of these conditions.