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Updated: Jul 30, 2026

Detection of Protein Palmitoylation in Cultured Hippocampal Neurons by Immunoprecipitation and Acyl-Biotin Exchange ABE
Published on: February 18, 2013
Slippery signaling: Palmitoylation-dependent control of neuronal kinase localization and activity
Audrey Montersino1, Gareth M Thomas1,2
1a Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair) and.
Abstract:
Modification of proteins with the lipid palmitate, a process called palmitoylation, is important for the normal function of neuronal cells. However, most attention has focused on how palmitoylation regulates the targeting and trafficking of neurotransmitter receptors and non-enzymatic scaffold proteins. In this review we discuss recent studies that suggest that palmitoylation also plays additional roles in neurons by controlling the localization, interactions and perhaps even the activity of protein kinases that play key roles in physiological neuronal regulation and in neuropathological processes.
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