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Related Concept Videos

Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
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Related Experiment Video

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Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
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Thermal Sensitivity and Dimethyl Sulfoxide (DMSO).

Kotaro Takeda1,2, Mieczyslaw Pokorski3,4, Yasumasa Okada1

  • 1Clinical Research Center, National Hospital Organization Murayama Medical Center, 2-37-1 Gakuen, Musashimurayama, 208-0011, Tokyo, Japan.

Advances in Experimental Medicine and Biology
|June 1, 2016
PubMed
Summary

Dimethyl sulfoxide (DMSO) did not alter thermal pain perception in mice. This study found no evidence of analgesic potential for DMSO in cutaneous heat stimulus tests.

Keywords:
AnalgesiaDimethyl sulfoxideNociceptionNoxious heatPainPerceptionThermal stimulus

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Pain Research

Background:

  • Dimethyl sulfoxide (DMSO) is a widely used solvent for hydrophobic compounds.
  • The inherent biological activities of DMSO, particularly its potential as an analgesic, are not well understood.
  • Limited research exists on DMSO's direct impact on pain perception.

Purpose of the Study:

  • To investigate the analgesic potential of Dimethyl sulfoxide (DMSO).
  • To assess DMSO's influence on the perception of thermal pain stimuli.
  • To evaluate the antinociceptive effects of various DMSO doses in a controlled experimental setting.

Main Methods:

  • Utilized a hotplate test with a 55°C stimulus in conscious mice.
  • Measured the latency of withdrawal behaviors as an indicator of thermal pain perception.
  • Administered incremental intraperitoneal doses of DMSO (0.5-15.5 g/kg) to the same cohort of mice sequentially.
  • Compared withdrawal latencies across different DMSO doses and pre-treatment control conditions.

Main Results:

  • Withdrawal latencies averaged 15-30 seconds across all tested DMSO doses.
  • No significant differences in withdrawal latency were observed between sequential DMSO conditions.
  • DMSO administration did not alter thermal pain perception compared to pre-DMSO control conditions.
  • Findings did not support DMSO's antinociceptive potential in this specific experimental model.

Conclusions:

  • Dimethyl sulfoxide (DMSO) did not demonstrate analgesic effects on cutaneous thermal pain perception in mice.
  • The study's findings contrast with some literature suggesting potential antinociceptive properties of DMSO.
  • Further research with alternative experimental designs is warranted to explore DMSO's effects on other pain types or in different biological contexts.