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Eruptive nevi associated with medications (ENAMs)
Benjamin M Perry1, Anne Nguyen2, Bryce L Desmond1
1Good Samaritan Regional Medical Center, Corvallis, Oregon; Silver Falls Dermatology, Salem, Oregon.
Journal of the American Academy of Dermatology
|June 1, 2016
Summary
Eruptive melanocytic nevi can be triggered by medications, particularly biologic therapies. This study defines and classifies medication-associated eruptive nevi for better understanding and diagnosis.
Area of Science:
- Dermatology
- Pharmacology
- Oncology
Background:
- Eruptive melanocytic nevi (EMN) are associated with various conditions, including severe blistering diseases, immunosuppression, and medications.
- Medication-associated EMN are increasingly reported, especially with the rise of biologic therapies.
Purpose of the Study:
- To define criteria for medication-associated eruptive nevi (MAEN).
- To develop a classification system for MAEN based on medication type.
- To review and summarize existing literature on MAEN.
Main Methods:
- Systematic literature search of PubMed/MEDLINE, Cochrane, and CINAHL databases.
- Keywords used: "eruptive nevi," "melanocytic + medications," and "nevi + medications."
- Analysis of identified articles to establish definitions and classifications.
Main Results:
- Findings were used to define MAEN.
- A classification system for MAEN by medication type was developed.
- The study highlights the growing association between biologic therapies and EMN.
Conclusions:
- Medication-induced eruptive melanocytic nevi are a recognized clinical entity.
- A standardized classification system is crucial for understanding and managing MAEN.
- Increased vigilance is needed for EMN in patients on biologic therapies.
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