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Updated: Mar 20, 2026
Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
Published on: October 25, 2024
T-bet promotes the accumulation of encephalitogenic Th17 cells in the CNS
Heather M Grifka-Walk1, Benjamin M Segal2
1Holtom-Garrett Program in Neuroimmunology, Department of Neurology, University of Michigan, 4014-B BSRB, 109 Zina Pitcher Drive, Ann Arbor, MI 48109-2200, USA; Graduate Program in Immunology, University of Michigan, 100 Medical Center Drive, Ann Arbor, MI 48109, USA.
Abstract:
T-bet enhances the encephalitogenicity of myelin-reactive CD4+ T cells, however its mechanism of action is unknown. In this study we show that T-bet confers a competitive advantage for the accumulation of IL-23 conditioned Th17 effector cells in the central nervous system (CNS). Impaired migration of T-bet deficient Th17 cells to the CNS is associated with altered expression of adhesion molecules and chemokine receptors on their cell surface. Our data suggest that therapeutic targeting of T-bet in individuals with Th17-mediated autoimmune demyelinating disease may inhibit inflammatory infiltration of the CNS and, hence, clinical exacerbations.
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